RapamycinFungusV1, Main, Exploration, bibRecord, 000313

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.

Identifieur interne : 000313 ( Main/Exploration ); précédent : 000312; suivant : 000314

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.

Source :

The Journal of infection [ 1532-2742 ] ; 2019.

RBID : pubmed:31226272

Descripteurs français

KwdFr :
- Autophagie (MeSH), Espèces réactives de l'oxygène (métabolisme), Facteur-1 de régulation d'interféron (métabolisme), Humains (MeSH), Interactions hôte-pathogène (MeSH), Macrophages (microbiologie), Macrophages (métabolisme), Monocytes (microbiologie), Monocytes (métabolisme), Monoxyde d'azote (métabolisme), Mycobacterium tuberculosis (physiologie), Ribosomal Protein S6 Kinases, 70-kDa (métabolisme), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH), Tuberculose (génétique), Tuberculose (microbiologie), Tuberculose (métabolisme).
MESH :
- génétique : Tuberculose.
- microbiologie : Macrophages, Monocytes, Tuberculose.
- métabolisme : Espèces réactives de l'oxygène, Facteur-1 de régulation d'interféron, Macrophages, Monocytes, Monoxyde d'azote, Ribosomal Protein S6 Kinases, 70-kDa, Sérine-thréonine kinases TOR, Tuberculose.
- physiologie : Mycobacterium tuberculosis.
- Autophagie, Humains, Interactions hôte-pathogène, Transduction du signal.

English descriptors

KwdEn :
- Autophagy (MeSH), Host-Pathogen Interactions (MeSH), Humans (MeSH), Interferon Regulatory Factor-1 (metabolism), Macrophages (metabolism), Macrophages (microbiology), Monocytes (metabolism), Monocytes (microbiology), Mycobacterium tuberculosis (physiology), Nitric Oxide (metabolism), Reactive Oxygen Species (metabolism), Ribosomal Protein S6 Kinases, 70-kDa (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism), Tuberculosis (genetics), Tuberculosis (metabolism), Tuberculosis (microbiology).
MESH :
- chemical , metabolism : Interferon Regulatory Factor-1, Nitric Oxide, Reactive Oxygen Species, Ribosomal Protein S6 Kinases, 70-kDa, TOR Serine-Threonine Kinases.
- genetics : Tuberculosis.
- metabolism : Macrophages, Monocytes, Tuberculosis.
- microbiology : Macrophages, Monocytes, Tuberculosis.
- physiology : Mycobacterium tuberculosis.
- Autophagy, Host-Pathogen Interactions, Humans, Signal Transduction.

Abstract

OBJECTIVES

Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it counteracts with mycobacterial infection in human remains largely obscure. This study was conducted to investigated the effect of IRF1 on Mtb infection in human macrophages (Mϕs).

METHODS

We thus investigated the IRF1 expression by using PBMC and monocytes of pulmonary tuberculosis (TB) patients and human monocyte-derived macrophages (hMDMs) and THP-1-derived macrophages (THP-1-Mϕ). We used gain-of-function and loss-of-function approaches to explore the role of IRF1 on Mtb infection.

RESULTS

IRF1 was significantly induced in PBMC and monocytes of pulmonary TB patients in vivo and in human Mϕs in vitro. We demonstrated that IRF1 protects Mϕs from Mtb infection. Concurrently, IRF1 promotes the expression of several pro-inflammatory cytokines including IL-6, TNF-α and IL-8, indicating IRF1-mediated activation of innate immunity upon Mtb infection. Gain-of-function and loss-of-function approaches have demonstrated that IRF1 suppresses the mechanistic target of rapamycin (mTOR)/p70 S6 kinase (p70 S6K) cascade to exert its anti-Mtb effect.

CONCLUSIONS

The discovery of a novel function of IRF1 in facilitating anti-mycobacterial effect through suppressing mTOR/p70 S6K signaling in Mϕs may provide a promoting therapeutic target for tuberculosis.

DOI: 10.1016/j.jinf.2019.06.007
PubMed: 31226272

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000246
to stream Main, to step Curation: 000246

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.</title>
<author><name sortKey="Zhou, Xinying" sort="Zhou, Xinying" uniqKey="Zhou X" first="Xinying" last="Zhou">Xinying Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Jiahui" sort="Yang, Jiahui" uniqKey="Yang J" first="Jiahui" last="Yang">Jiahui Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Zelin" sort="Zhang, Zelin" uniqKey="Zhang Z" first="Zelin" last="Zhang">Zelin Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Lijie" sort="Zhang, Lijie" uniqKey="Zhang L" first="Lijie" last="Zhang">Lijie Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lie, Linmiao" sort="Lie, Linmiao" uniqKey="Lie L" first="Linmiao" last="Lie">Linmiao Lie</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Bo" sort="Zhu, Bo" uniqKey="Zhu B" first="Bo" last="Zhu">Bo Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Lei" sort="Xu, Lei" uniqKey="Xu L" first="Lei" last="Xu">Lei Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Northwest A&F University, Yangling 712100, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Life Sciences, Northwest A&F University, Yangling 712100</wicri:regionArea>
<wicri:noRegion>Yangling 712100</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Yuchi" sort="Gao, Yuchi" uniqKey="Gao Y" first="Yuchi" last="Gao">Yuchi Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Du, Xialin" sort="Du, Xialin" uniqKey="Du X" first="Xialin" last="Du">Xialin Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Yingqi" sort="Huang, Yingqi" uniqKey="Huang Y" first="Yingqi" last="Huang">Yingqi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Ruining" sort="Wang, Ruining" uniqKey="Wang R" first="Ruining" last="Wang">Ruining Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Honglin" sort="Liu, Honglin" uniqKey="Liu H" first="Honglin" last="Liu">Honglin Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yanfen" sort="Li, Yanfen" uniqKey="Li Y" first="Yanfen" last="Li">Yanfen Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Shengfeng" sort="Hu, Shengfeng" uniqKey="Hu S" first="Shengfeng" last="Hu">Shengfeng Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Chaoying" sort="Zhou, Chaoying" uniqKey="Zhou C" first="Chaoying" last="Zhou">Chaoying Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wen, Qian" sort="Wen, Qian" uniqKey="Wen Q" first="Qian" last="Wen">Qian Wen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pan, Qiuwei" sort="Pan, Qiuwei" uniqKey="Pan Q" first="Qiuwei" last="Pan">Qiuwei Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduated School Molecular Medicine, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduated School Molecular Medicine, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Li" sort="Ma, Li" uniqKey="Ma L" first="Li" last="Ma">Li Ma</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China. Electronic address: mali_61648322@smu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31226272</idno>
<idno type="pmid">31226272</idno>
<idno type="doi">10.1016/j.jinf.2019.06.007</idno>
<idno type="wicri:Area/Main/Corpus">000246</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000246</idno>
<idno type="wicri:Area/Main/Curation">000246</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000246</idno>
<idno type="wicri:Area/Main/Exploration">000246</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.</title>
<author><name sortKey="Zhou, Xinying" sort="Zhou, Xinying" uniqKey="Zhou X" first="Xinying" last="Zhou">Xinying Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Jiahui" sort="Yang, Jiahui" uniqKey="Yang J" first="Jiahui" last="Yang">Jiahui Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Zelin" sort="Zhang, Zelin" uniqKey="Zhang Z" first="Zelin" last="Zhang">Zelin Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Lijie" sort="Zhang, Lijie" uniqKey="Zhang L" first="Lijie" last="Zhang">Lijie Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lie, Linmiao" sort="Lie, Linmiao" uniqKey="Lie L" first="Linmiao" last="Lie">Linmiao Lie</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Bo" sort="Zhu, Bo" uniqKey="Zhu B" first="Bo" last="Zhu">Bo Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Lei" sort="Xu, Lei" uniqKey="Xu L" first="Lei" last="Xu">Lei Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Northwest A&F University, Yangling 712100, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Life Sciences, Northwest A&F University, Yangling 712100</wicri:regionArea>
<wicri:noRegion>Yangling 712100</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Yuchi" sort="Gao, Yuchi" uniqKey="Gao Y" first="Yuchi" last="Gao">Yuchi Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Du, Xialin" sort="Du, Xialin" uniqKey="Du X" first="Xialin" last="Du">Xialin Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Yingqi" sort="Huang, Yingqi" uniqKey="Huang Y" first="Yingqi" last="Huang">Yingqi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Ruining" sort="Wang, Ruining" uniqKey="Wang R" first="Ruining" last="Wang">Ruining Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Honglin" sort="Liu, Honglin" uniqKey="Liu H" first="Honglin" last="Liu">Honglin Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yanfen" sort="Li, Yanfen" uniqKey="Li Y" first="Yanfen" last="Li">Yanfen Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Shengfeng" sort="Hu, Shengfeng" uniqKey="Hu S" first="Shengfeng" last="Hu">Shengfeng Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Chaoying" sort="Zhou, Chaoying" uniqKey="Zhou C" first="Chaoying" last="Zhou">Chaoying Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wen, Qian" sort="Wen, Qian" uniqKey="Wen Q" first="Qian" last="Wen">Qian Wen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pan, Qiuwei" sort="Pan, Qiuwei" uniqKey="Pan Q" first="Qiuwei" last="Pan">Qiuwei Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduated School Molecular Medicine, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduated School Molecular Medicine, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Li" sort="Ma, Li" uniqKey="Ma L" first="Li" last="Ma">Li Ma</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China. Electronic address: mali_61648322@smu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of infection</title>
<idno type="eISSN">1532-2742</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagy (MeSH)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Interferon Regulatory Factor-1 (metabolism)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (microbiology)</term>
<term>Monocytes (metabolism)</term>
<term>Monocytes (microbiology)</term>
<term>Mycobacterium tuberculosis (physiology)</term>
<term>Nitric Oxide (metabolism)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Tuberculosis (genetics)</term>
<term>Tuberculosis (metabolism)</term>
<term>Tuberculosis (microbiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (MeSH)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Facteur-1 de régulation d'interféron (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
<term>Macrophages (microbiologie)</term>
<term>Macrophages (métabolisme)</term>
<term>Monocytes (microbiologie)</term>
<term>Monocytes (métabolisme)</term>
<term>Monoxyde d'azote (métabolisme)</term>
<term>Mycobacterium tuberculosis (physiologie)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (métabolisme)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
<term>Tuberculose (génétique)</term>
<term>Tuberculose (microbiologie)</term>
<term>Tuberculose (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon Regulatory Factor-1</term>
<term>Nitric Oxide</term>
<term>Reactive Oxygen Species</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tuberculose</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
<term>Monocytes</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Macrophages</term>
<term>Monocytes</term>
<term>Tuberculose</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term>
<term>Monocytes</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term>
<term>Facteur-1 de régulation d'interféron</term>
<term>Macrophages</term>
<term>Monocytes</term>
<term>Monoxyde d'azote</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Tuberculose</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Autophagy</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it counteracts with mycobacterial infection in human remains largely obscure. This study was conducted to investigated the effect of IRF1 on Mtb infection in human macrophages (Mϕs).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We thus investigated the IRF1 expression by using PBMC and monocytes of pulmonary tuberculosis (TB) patients and human monocyte-derived macrophages (hMDMs) and THP-1-derived macrophages (THP-1-Mϕ). We used gain-of-function and loss-of-function approaches to explore the role of IRF1 on Mtb infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>IRF1 was significantly induced in PBMC and monocytes of pulmonary TB patients in vivo and in human Mϕs in vitro. We demonstrated that IRF1 protects Mϕs from Mtb infection. Concurrently, IRF1 promotes the expression of several pro-inflammatory cytokines including IL-6, TNF-α and IL-8, indicating IRF1-mediated activation of innate immunity upon Mtb infection. Gain-of-function and loss-of-function approaches have demonstrated that IRF1 suppresses the mechanistic target of rapamycin (mTOR)/p70 S6 kinase (p70 S6K) cascade to exert its anti-Mtb effect.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The discovery of a novel function of IRF1 in facilitating anti-mycobacterial effect through suppressing mTOR/p70 S6K signaling in Mϕs may provide a promoting therapeutic target for tuberculosis.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31226272</PMID>
<DateCompleted><Year>2020</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>07</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>79</Volume>
<Issue>3</Issue>
<PubDate><Year>2019</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of infection</Title>
<ISOAbbreviation>J Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.</ArticleTitle>
<Pagination><MedlinePgn>262-276</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0163-4453(19)30187-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2019.06.007</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES">Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it counteracts with mycobacterial infection in human remains largely obscure. This study was conducted to investigated the effect of IRF1 on Mtb infection in human macrophages (Mϕs).</AbstractText>
<AbstractText Label="METHODS">We thus investigated the IRF1 expression by using PBMC and monocytes of pulmonary tuberculosis (TB) patients and human monocyte-derived macrophages (hMDMs) and THP-1-derived macrophages (THP-1-Mϕ). We used gain-of-function and loss-of-function approaches to explore the role of IRF1 on Mtb infection.</AbstractText>
<AbstractText Label="RESULTS">IRF1 was significantly induced in PBMC and monocytes of pulmonary TB patients in vivo and in human Mϕs in vitro. We demonstrated that IRF1 protects Mϕs from Mtb infection. Concurrently, IRF1 promotes the expression of several pro-inflammatory cytokines including IL-6, TNF-α and IL-8, indicating IRF1-mediated activation of innate immunity upon Mtb infection. Gain-of-function and loss-of-function approaches have demonstrated that IRF1 suppresses the mechanistic target of rapamycin (mTOR)/p70 S6 kinase (p70 S6K) cascade to exert its anti-Mtb effect.</AbstractText>
<AbstractText Label="CONCLUSIONS">The discovery of a novel function of IRF1 in facilitating anti-mycobacterial effect through suppressing mTOR/p70 S6K signaling in Mϕs may provide a promoting therapeutic target for tuberculosis.</AbstractText>
<CopyrightInformation>Copyright © 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Xinying</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Jiahui</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Zelin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Lijie</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lie</LastName>
<ForeName>Linmiao</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Bo</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>College of Life Sciences, Northwest A&F University, Yangling 712100, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Yuchi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Du</LastName>
<ForeName>Xialin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yingqi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Ruining</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Honglin</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yanfen</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Shengfeng</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Chaoying</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Qian</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Qiuwei</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center and Postgraduated School Molecular Medicine, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China. Electronic address: mali_61648322@smu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>06</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Infect</MedlineTA>
<NlmUniqueID>7908424</NlmUniqueID>
<ISSNLinking>0163-4453</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050856">Interferon Regulatory Factor-1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber>
<NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D038762">Ribosomal Protein S6 Kinases, 70-kDa</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050856" MajorTopicYN="N">Interferon Regulatory Factor-1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009000" MajorTopicYN="N">Monocytes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009169" MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D038762" MajorTopicYN="N">Ribosomal Protein S6 Kinases, 70-kDa</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Interferon regulatory factor 1 (IRF1)</Keyword>
<Keyword MajorTopicYN="Y">Macrophages (Mϕs)</Keyword>
<Keyword MajorTopicYN="Y">Mechanistic target of rapamycin signaling (mTOR)</Keyword>
<Keyword MajorTopicYN="Y">Mycobacterium tuberculosis (Mtb)</Keyword>
<Keyword MajorTopicYN="Y">p70 S6 kinase (p70 S6K)</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>12</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>04</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>06</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>6</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>7</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>6</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31226272</ArticleId>
<ArticleId IdType="pii">S0163-4453(19)30187-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.jinf.2019.06.007</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Pays-Bas</li>
<li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
<li>Hollande-Méridionale</li>
</region>
<settlement><li>Jiangmen</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhou, Xinying" sort="Zhou, Xinying" uniqKey="Zhou X" first="Xinying" last="Zhou">Xinying Zhou</name>
</region>
<name sortKey="Du, Xialin" sort="Du, Xialin" uniqKey="Du X" first="Xialin" last="Du">Xialin Du</name>
<name sortKey="Gao, Yuchi" sort="Gao, Yuchi" uniqKey="Gao Y" first="Yuchi" last="Gao">Yuchi Gao</name>
<name sortKey="Hu, Shengfeng" sort="Hu, Shengfeng" uniqKey="Hu S" first="Shengfeng" last="Hu">Shengfeng Hu</name>
<name sortKey="Huang, Yingqi" sort="Huang, Yingqi" uniqKey="Huang Y" first="Yingqi" last="Huang">Yingqi Huang</name>
<name sortKey="Li, Yanfen" sort="Li, Yanfen" uniqKey="Li Y" first="Yanfen" last="Li">Yanfen Li</name>
<name sortKey="Lie, Linmiao" sort="Lie, Linmiao" uniqKey="Lie L" first="Linmiao" last="Lie">Linmiao Lie</name>
<name sortKey="Liu, Honglin" sort="Liu, Honglin" uniqKey="Liu H" first="Honglin" last="Liu">Honglin Liu</name>
<name sortKey="Ma, Li" sort="Ma, Li" uniqKey="Ma L" first="Li" last="Ma">Li Ma</name>
<name sortKey="Wang, Ruining" sort="Wang, Ruining" uniqKey="Wang R" first="Ruining" last="Wang">Ruining Wang</name>
<name sortKey="Wen, Qian" sort="Wen, Qian" uniqKey="Wen Q" first="Qian" last="Wen">Qian Wen</name>
<name sortKey="Xu, Lei" sort="Xu, Lei" uniqKey="Xu L" first="Lei" last="Xu">Lei Xu</name>
<name sortKey="Yang, Jiahui" sort="Yang, Jiahui" uniqKey="Yang J" first="Jiahui" last="Yang">Jiahui Yang</name>
<name sortKey="Zhang, Lijie" sort="Zhang, Lijie" uniqKey="Zhang L" first="Lijie" last="Zhang">Lijie Zhang</name>
<name sortKey="Zhang, Zelin" sort="Zhang, Zelin" uniqKey="Zhang Z" first="Zelin" last="Zhang">Zelin Zhang</name>
<name sortKey="Zhou, Chaoying" sort="Zhou, Chaoying" uniqKey="Zhou C" first="Chaoying" last="Zhou">Chaoying Zhou</name>
<name sortKey="Zhu, Bo" sort="Zhu, Bo" uniqKey="Zhu B" first="Bo" last="Zhu">Bo Zhu</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Pan, Qiuwei" sort="Pan, Qiuwei" uniqKey="Pan Q" first="Qiuwei" last="Pan">Qiuwei Pan</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000313 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31226272
   |texte=   Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31226272" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki